BernheimV1, Main, Exploration, bibRecord, 000B10

A molecular genetic linkage map of mouse chromosome 4 including the localization of several proto-oncogenes

Identifieur interne : 000B10 ( Main/Exploration ); précédent : 000B09; suivant : 000B11

A molecular genetic linkage map of mouse chromosome 4 including the localization of several proto-oncogenes

Auteurs : Jeffrey D. Ceci [États-Unis] ; Linda D. Siracusa [États-Unis] ; Nancy A. Jenkins [États-Unis] ; Neal G. Copeland [États-Unis]

Source :

Genomics [ 0888-7543 ] ; 1989.

RBID : ISTEX:E0AC850D7CFDB02E857A67B78D6E1E06F9913532

English descriptors

Teeft :
- Acad, Acute lymphoblastic leukemia, Acute nonlymphocytic leukemia, Allele, Backcross, Cancer genet, Ceci, Chromosomal, Chromosome, Deletion, Gene, Gene order, Genet, Homolog, Human chromosome, Human gene, Interferon, Interspecific, Interspecific backcross, Interspecific backcross analysis, Kinase, Leukemia, Linkage, Lmyc, Localization, Locus, Lymphoma, Mouse, Mouse chromosome, Murine, Mutation, Nadeau, Natl, Neuroblastoma, Oncogene, Proc, Recombinant, Recombination, Rflp, Rrm2, Siracusa, Somatic cell, Spretus, Spretus alleles, Synteny, Translocation, Transmission ratio distortion, Tsha, Unpublished results, Vande, Vande woude, Viral, Viral integration.

Abstract

Abstract: We have constructed a 64-cM molecular genetic linkage map of mouse chromosome 4 using interspecific backcross animals derived from mating C57BL 6J and Mus spretus mice. Several proto-oncogenes and common sites of viral integration have been assigned regional locations on chromosome 4 including Mos, Lyn, Jun, Lmyc, Lek, Fgr, and Dsi-1. Additional loci mapped in this study to chromosome 4 were Tsha, Mup-1, Rrm2-ps1, Ifa, and Anf. A comparison of our mapping data with inbred strain mapping data did not show any evidence for inversions or deletions on chromosome 4. New regions of synteny were defined between mouse chromosome 4 and human chromosomes 1 and 8; a region of homology was found between mouse chromosome 4 and human chromosome 6. This linkage map will provide a framework for identifying homologous genes in mice and humans that may be involved in various disease processes.

Url:

https://api.istex.fr/document/E0AC850D7CFDB02E857A67B78D6E1E06F9913532/fulltext/pdf

DOI: 10.1016/0888-7543(89)90111-0

Affiliations:

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Le document en format XML

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<term>Unpublished results</term>
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<front><div type="abstract" xml:lang="en">Abstract: We have constructed a 64-cM molecular genetic linkage map of mouse chromosome 4 using interspecific backcross animals derived from mating C57BL 6J and Mus spretus mice. Several proto-oncogenes and common sites of viral integration have been assigned regional locations on chromosome 4 including Mos, Lyn, Jun, Lmyc, Lek, Fgr, and Dsi-1. Additional loci mapped in this study to chromosome 4 were Tsha, Mup-1, Rrm2-ps1, Ifa, and Anf. A comparison of our mapping data with inbred strain mapping data did not show any evidence for inversions or deletions on chromosome 4. New regions of synteny were defined between mouse chromosome 4 and human chromosomes 1 and 8; a region of homology was found between mouse chromosome 4 and human chromosome 6. This linkage map will provide a framework for identifying homologous genes in mice and humans that may be involved in various disease processes.</div>
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Serveur d'exploration Hippolyte Bernheim

A molecular genetic linkage map of mouse chromosome 4 including the localization of several proto-oncogenes

A molecular genetic linkage map of mouse chromosome 4 including the localization of several proto-oncogenes

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri